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    of the enzyme inducers rifampicin and rifabutin suggest that metabolism of clarithromycin by CYP3A4 is elevated.
    Roxithromycin-induced generalized urticaria and tachycardia with a positive prick take a look at and
    a cross-reaction to erythromycin and clarithromycin has been reported in a 31-year-previous
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    clarithromycin (0.35 episodes/affected person-day).

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