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    While the total physique clearance of theophylline fell and plasma theophylline concentrations increased by 18%,
    imply theophylline concentrations remained within the goal vary.
    Clarithromycin inhibits the metabolism of pimozide, pimozide plasma
    concentrations enhance, and there may be an increased danger
    of cardiotoxicity by prolongation of the QT interval
    and fatal ventricular dysrhythmias. The modifications in serum concentrations of clarithromycin and its metabolite within the presence
    of the enzyme inducers rifampicin and rifabutin suggest that metabolism of clarithromycin by CYP3A4 is elevated.
    Roxithromycin-induced generalized urticaria and tachycardia with a positive prick take a look at and
    a cross-reaction to erythromycin and clarithromycin has been reported in a 31-year-previous
    woman. In a prospective, non-randomized research, phlebitis occurred in 15 of 19 patients treated with intravenous erythromycin (incidence price of 0.40
    episodes/patient-day) and in 19 of 25 patients treated with intravenous
    clarithromycin (0.35 episodes/affected person-day).

    Of instances of mania attributed to antibiotics and reported
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